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What is Pradaxa?
Pradaxa is an anticoagulant medication that helps prevent dangerous blood clots from forming in the body. It was first approved by the FDA in 2010 and can be used for several purposes:
- Prevent blood clots after hip or knee replacement surgery.
- Prevent stroke and systemic embolism in adults with a heart condition called non-valvular atrial fibrillation.
- Treat deep vein thrombosis (DVT) and pulmonary embolism (PE) in adults.
- Treat and prevent recurrent blood clots in children over eight years old.
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How Does Pradaxa Work?
Pradaxa contains the active ingredient dabigatran etexilate. After you swallow Pradaxa, the dabigatran etexilate is quickly converted to its active form, dabigatran.
Dabigatran belongs to a group of medications called “blood thinners” or anticoagulants. It works by blocking the activity of thrombin, a protein that plays a key role in clot formation. When thrombin is inhibited, it's harder for blood clots to develop.
Pradaxa Dosages
Pradaxa is available in tablet form with three different dosages: 75 mg, 110 mg, and 150 mg.
The specific dosage you will be prescribed depends on the condition being treated. While we have included the FDA-recommended dosages below, it is important to note that your doctor will ultimately determine the dosage based on your medical history. Additionally, your dosage may also be influenced by your kidney function.
- Non-valvular atrial fibrillation in adults: 150 mg orally, twice daily.
- Treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) in adults: 150 mg orally, twice daily.
- Reducing the risk of DVT and PE recurrence in adults: 150 mg orally, twice daily.
- Reducing the risk of DVT and PE after hip replacement surgery in adults: 110 mg orally on the first day and then 220 mg once daily afterward.
- For children, the appropriate dosage is determined based on their weight and will be specified by their doctor.
Pradaxa Side Effects
Pradaxa can sometimes lead to mild or serious side effects in certain individuals. It is crucial to be aware of these potential side effects and immediately inform your doctor if you experience any concerning symptoms after starting Pradaxa.
Mild Pradaxa side effects include:
- Easily bruising or bleeding
- Heartburn
- Upset stomach
- Stomach pain
Serious Pradaxa side effects include:
- Increased risk of blood clots when stopping Pradaxa
- Blood clots in or around your spine
- Allergic reaction
- Severe bleeding
FAQs
What is Pradaxa used for?
Pradaxa is an anticoagulant medication that has been approved by the Food and Drug Administration (FDA) to reduce the risk of developing dangerous blood clots.
Blood clots can form in the deep veins of the legs, known as deep vein thrombosis or in the lungs, called pulmonary embolism. Both deep vein thrombosis and pulmonary embolism are serious medical conditions that can lead to long-term health complications or even death.
How do I store Pradaxa?
Store Pradaxa at room temperature between 68- and 77-degrees Fahrenheit. Keep the tablets in their original packaging and store them in a cool, dry location away from extreme heat, cold, and humidity. A good spot is a drawer, cabinet, or closet away from children and pets. Avoid placing it in the bathroom, as the humidity can impact the medication.
Is Pradaxa more effective than warfarin?
Warfarin (also known as Coumadin) has been on the market for decades. Unlike newer anticoagulants like Pradaxa, warfarin works by blocking vitamin K, an essential component for proper blood clotting.
While highly effective, warfarin requires frequent monitoring and dosage adjustments through blood tests every 12 weeks. Patients must also watch their vitamin K intake, which can impact warfarin’s effectiveness. The newer Pradaxa does not have these dietary restrictions or need for frequent testing.
In one study comparing Pradaxa and warfarin, Pradaxa was found to be more effective. The death rate from any cause was 3.6% per year for those on Pradaxa compared to 4.1% per year for those on warfarin. The death rate due to vascular causes was also lower for Pradaxa at 2.3% compared to 2.7% for warfarin.
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